Quercetin, an Artificial Regulator of the High Aerobic Glycolysis of Tumor Cells 1 2
- 1 November 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 53 (5) , 1515-1519
- https://doi.org/10.1093/jnci/53.5.1515
Abstract
We showed that the high aerobic glycolysis observed in several tumor cells was caused by high ATPase activity. In some tumors, the ATPase activity of the Na+K+ pump was responsible; in some, the mitochondrial ATPase; and in others, an unidentified ATPase generated ADP and Pi required for glycolysis. In the cells analyzed thus far, the increased ATPase activity was not due to an increased function of the pump but to a loss of the control mechanism responsible for tight coupling. Some bioflavonoids inhibit the aerobic glycolysis by specifically repairing the defective control mechanism.Keywords
This publication has 0 references indexed in Scilit: