Effect of the Proton Pump Inhibitor, NC-1300, on Gastric Mucus Secretion in Rats
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 24 (sup162) , 186-189
- https://doi.org/10.3109/00365528909091157
Abstract
The effects of NC-1300 on gastric acid and mucus glycoprotein secretion were investigated in pylorus-ligated (4 h) rats. NC-1300 (30 mg/kg, intraduodenally) significantly inhibited gastric acid concentration more than 90 %. The agent did not affect the total mucus glycoprotein output in the gastric juice, but caused by about 1.5 times denser mucus glycoprotein secretion than that in the control group. The amount of mucus glycoprotein in the mucous gel layer increased by about 1.4 times with this agent. Thus, NC-1300 not only inhibits acid secretion but also promotes mucus secretion, and this may explain its ability to protect the stomach against necrotizing agents.Keywords
This publication has 1 reference indexed in Scilit:
- Cytoprotective Effects of NC-1300 and Omeprazole on HCl⋅Ethanol-Induced Gastric Lesions in RatsThe Japanese Journal of Pharmacology, 1986