Placental Metabolism and Enzyme Activities in Diabetic Pigs

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Abstract
Placental tissue metabolism and enzyme activities were measured in alloxan diabetic pigs and compared to other tissues. The pig placenta is made up of 2 placentas, maternal and fetal. These 2 placentas had different rates of glucose, pyruvate and alanine utilization. The fetal placenta had higher activities of aspartate aminotransferase when compared to maternal liver and placenta. Diabetes resulted in a decrease in maternal placenta de novo fatty acid synthesis and activity of glucose-6-phosphate dehydrogenase. There may be a metabolic regulatory role for this organ during pregnancy.