ACTION OF CHLORAMPHENICOL ON T-1 BACTERIOPHAGE I

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Abstract
Bactertostatlc concns. of chloramphenicol inhibit intracellular growth of T1 bacteriophage in Escherlchla coli, strain B. The drug has no direct virucidal action and does not prevent adsorption of the phage onto the bacterium. Chloramphenicol interrupts phage maturation at any stage in the latent period. A bacteriostatic concn. of the antibiotic added early in the latent period inhibits lysis and prevents formation of new infective phage particles. In the presence of the same drug concn. added late in the latent period, lysis occurs at the usual time. The no. of phage particles released on lysis approximates the no. completed at the time the drug was introduced. Chloramphenicol inhibition of the early phases of the latent period is partially reversible.