Experimental Study on the Mechanism of Formation of Calcium Carbonate Stones

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Abstract
A theory of calculus formation was previously published that components of a calculus separated from colloidal body fluid are coagulated and solidified by electrostatic effect of electrolytes, bridging action of high-molecular-weight organic substances, and kinetic energy supplied from the organism. In support of this theory, gallstone-like concrements of calcium bilirubinate were produced as well as bezoar-like coagulates of persimmon in vitro. This paper is concerned with the developmental mechanism of calcium carbonate stones which occur most commonly in human being. When a suspension of precipitated calcium carbonate was supplemented with proper combination of an inorganic electrolyte and an organic poly-electrolyte and then rotated in a flask, it eventually yielded solid concrements of calcium carbonate that resembled genuine calcium carbonate stones. Accordingly, it was shown that the theory is valid in formation of this kind of calculi.

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