DNA sequences similar to those around the simian virus 40 origin of replication are present in the monkey genome.

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Abstract
African green monkey genomic DNA segments that include regions of homology to the origin of replication of SV40 were cloned. Three clearly different cloned segments 14-17 kilobase pairs (kb) long were isolated from a genomic library in .lambda. phage. Each segment is probably repeated < 4 times in the monkey genome. The SV40-like regions represent a small portion of the cloned segments, and the regions cross hybridize only weakly with one another. One of 3 segments is described in detail. Although the entire segment occurs only once or twice in the monkey genome, it contains DNA sequences (other than the SV40-like sequences) that are repeated elsewhere in the genome including in the other 2 cloned segments. The homology to SV40 is contained within about 300 base pairs of monkey DNA and is limited to the region around the viral replication origin. The nucleotide sequence of the SV40-like region was determined. It contains a large number of short stretches homologous to 3 specific noncoding domains around the SV40 origin of replication: the 27 base pair region of dyad symmetry, the 1st set of (short) repeats that occur just on the late side of the origin, and, further in the late direction, the two 72 base pair-long repeats. These components are grouped in the monkey DNA as they are in SV40 DNA, but their relative juxtaposition is scrambled.