Continuous removal of anti‐DNA antibody, using a new extracorporeal immunoadsorption system, in patients with systemic lupus erythematosus

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Abstract
We performed selective and continuous immunoadsorption of anti‐DNA antibodies from the blood of 6 patients with systemic lupus erythematosus, using a newly developed extracorporeal immunoadsorption system equipped with twin dextran sulfate‐cellulose columns with an automated regenerating unit. Levels of anti‐DNA, which were initially high, were rapidly diminished after 2–4 apheresis procedures in each patient; in 3 patients with proteinuria and 4 patients with lymphocytopenia, these symptoms also improved. Analysis of the kinetics and the adsorbed amounts of anti‐DNA during the apheresis indicates that both the intravascular and the extravascular pool of anti‐DNA are reduced with this potent apheresis technique.

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