In 124 medically inoperable patients with endometrial cancer, the five and ten year actuarial survival rates were 68% and 57%. In 26 patients with technically unresectable endometrial cancer, 26% actuarial survival rates at both five and ten years were seen. Pelvic control at death was 89% in Stage Ia, 78% in Stage Ib, 82% in Stage II, and 62% in Stage III. Sophisticated intracavitary therapy alone or in conjunction with external irradiation appears to give better uterine control rates than does external irradiation alone.