TREATMENT OF TYPHOID FEVER BY INTRAVENOUS INJECTIONS OF POLYVALENT SENSITIZED TYPHOID VACCINE SEDIMENT

Open Access

1 February 1916

journal article
research article
Published by American Medical Association (AMA) in Archives of internal medicine (1908)

Vol. XVII (2) , 303-328
https://doi.org/10.1001/archinte.1916.00080080125009

Abstract

Since the work of Fraenkel¹in 1893, killed preparations of the typhoid bacillus have been injected subcutaneously as a means of treatment in typhoid fever. Little interest was at first awakened by the suggestive results of Fraenkel except in a discussion of the specificity of his treatment (Rumpf,²Kraus and Buswell,³Presser.⁴) In 1902 Petruschy⁵used a combination of vaccine and immune serum in typhoid, and in 1908 Pescarolo and Quadrone⁶advocated the use of a living, avirulent typhoid culture. Following the interest in vaccine therapy awakened by Wright, increasingly frequent reports on the possible value of typhoid vaccines in typhoid fever have appeared. In 1912 Callison⁷summarized the results obtained by numerous authors, chiefly English and American, in 747 cases, and in 1915 Krumbhaar and Richardson⁸could collect over 1,800 cases reported on by forty authors. It is known that many

This publication has 1 reference indexed in Scilit:

THE VALUE OF TYPHOID VACCINES IN THE TREATMENT OF TYPHOID FEVER
The Lancet Healthy Longevity, 1915