Effects of Elevated Intracellular ATP and GTP Concentrations on Purine Ribonucleotide Synthesis and Interconversion

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Abstract
The effects of elevated intracellular ATP and GTP concentrations on enzymes of purine ribonucleotide synthesis and interconversion were examined in intact Ehrlich ascites tumor cells. Elevated ATP and GTP concentrations inhibit nucleotide synthesis from purine bases up to 50% and elevated concentrations of GTP severely inhibit IMP dehydrogenase (60%). In contrast, adenylate deaminase activity was inhibited 16% at the highest concentration of GTP studied and elevated ATP concentrations had only a slight inhibitory effect on adenylosuccinate synthetase plus lyase (9%).