Failure of Homozygous Embryo Skin to Prevent Growth of Autogenous Tumor-Grafts in the Rat.

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Abstract
In a previous communication the author demonstrated the possibility of inducing a resistant state in an inbred strain of rats (Baggs) to a lymphosarcoma autogenous to the strain. This was accomplished by implanting tumor grafts previously attenuated in vitro with specific doses of x-rays. The question arose whether or not similar results may be obtained by the use of embryo skin of the same strain of rats. Previous investigators have been able to induce a resistant state in hybrid animals to malignant growth including leukemias by injecting normal homologous tissues, such as liver, spleen, blood. Skin, however, proved to be the most potent agent. Fifteen rats of the pure line (Baggs) strain were implanted with embryo skin autogenous to the strain. Twelve days later the same rats were implanted with the lymphosarcoma autogenous to the strain. Fourteen of the 15 rats developed tumors within 12-14 days following transplantation. It was therefore concluded that inoculation of embryo skin into rats of the same genetic constitution failed to elicit a resistant state to a tumor autogenous to the strain. From the previous and present expts., it seems likely that the type of tumor may be responsible for the specific immune action in inbred strains of rats.

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