Synthesis of cyclic peptide homologs of glutathione as potential antitumor agents
- 12 January 1990
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 35 (1) , 55-62
- https://doi.org/10.1111/j.1399-3011.1990.tb00721.x
Abstract
Two cyclic tripeptide homologs, cyclo(Glu[Cys-β-Ala-]-OH) 8a, and cyclo(Glu[Cys-Gaba-]-OH) 8b, were synthesized by the pentafluorophenyl ester method in solution (1-3). These cyclic peptides are cyclo homologs of glutathione and are designed as potential antitumor agents. The 1H- and 13C-n.m.r. spectral parameters of cyclo(Glu[Cys(Bzl)-β-Ala-]-OH) 7a were measured in DMSO-d6 and a possible conformation has been proposed. The cyclic peptide 8a showed low cytotoxic activities against three human tumor cell lines: KB, HeLa, and Colo 205.Keywords
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