Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology

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Abstract
Methylenedioxyamphetamine is a commonly used street drug, with a reputation of providing a good trip. The drug is structurally similar to mescaline and amphetamine. The following symptoms were found in a patient: sympathomimetic effects, coma, seizures, hyperreflexia and hyperthermia. The patient''s condition was initially stabilized and then deteriorated with uncontrollable hyperthermia, hematologic abnormalities, and coma that culminated in death. Since the hyperthermia was based on central and peripheral mechanisms, phentolamine (Regitine) mesylate may be the preferred drug to be used in the treatment of future cases. The concept that this drug was primarily a hallucinogen with mild toxicity was erroneous.

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