The anatomy and development of the mutants pirouette, shaker-1 and waltzer in the mouse

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Abstract
The genes v, sh-1 and pi all have the same general effect on the labyrinth. The organ of Corti, spiral ganglion, stria vascularis and the saccular macula degenerate in all three mutants. The cristae are normal in v/v and sh-1/sh-1 but are affected in pi/pi mice. The average size of the vestibular ganglion cells is reduced in sh-1/sh-1 and pi/pi but not in v/v mice. The degeneration of the vestibular part of the labyrinth observed in the mutant shaker-1 is contrary to the previous reports on this mutant. In general, the anomalies discussed here closely resemble those in the other mutants of this group, namely, Varitint-waddler, jerker and shaker-2. But each mutant has some characteristic feature which is not seen in the others.