Palladium Catalysts for Aerobic Oxidative Kinetic Resolution of Secondary Alcohols Based on Mechanistic Insight
- 14 December 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (1) , 63-65
- https://doi.org/10.1021/ol027190y
Abstract
The oxidative kinetic resolution of secondary alcohols has been accomplished using 1:1 complexes of PdCl2 and N-heterocyclic carbenes. In these reactions, both achiral and chiral carbene ligands are used in conjunction with the chiral base (−)-sparteine. A general synthesis of 1:1 PdCl2−carbene complexes has been developed and is amenable to a wide range of carbene ligands. The potential of these complexes in aerobic oxidations is highlighted by the use of a chiral Pd(II) complex and the chiral base (−)-sparteine to enhance the kinetic resolution of a racemic alcohol.Keywords
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