Antibacillin, a Naturally Occurring Inhibitor of Bacillin
- 1 March 1946
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 51 (3) , 371-380
- https://doi.org/10.1128/jb.51.3.371-380.1946
Abstract
Naturally occurring complex organic materials contain an organic substance, herein named "antibacillin," which counteracts the antibacterial action of the antibiotic bacillin. Inorganic salts and H2S also have this property. Antibacillin is liberated on hydrolysis of gelatin or casein. It does not destroy or combine with bacillin but probably acts competitively with the latter for vital systems in susceptible bacteria. The chemical properties of antibacillin are given as well as details for the prepn. of concentrates of the active fraction from gelatin and from P enicillium notatum mycelium.Keywords
This publication has 3 references indexed in Scilit:
- Inactivation of the Antibiotic Activity of Penicillin by Cysteine Hydrochloride. I. Chemical Aspects of InactivationExperimental Biology and Medicine, 1945
- The Mechanism of the Antibiotic Action of Clavacin and Penicillic Acid1,2Journal of the American Chemical Society, 1945
- PRELIMINARY NOTE ON THE INACTIVATION OF ANTIBIOTICSScience, 1944