Attenuation of the goose parvovirus strain B. laboratory and field trials of the attenuated mutant for vaccination against Derzsy's disease

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Abstract
Serial transfer of the goose parvovirus strain B, causal agent of Derzsy''s gosling disease, in cultured goose-embryo fibroblast (GEF) resulted in a mutant (designated as Bav) apathogenic for both goose embryos and susceptible goslings. Goose embryos inoculated with the 38th or higher passages of strain B survived the infection, although the virus replicated in their organs. Susceptible goslings survived challenge with the Bav strain without showing symptoms, and developed normally. Only 4.2% of gosling progeny of parents vaccinated twice with strain Bav died after challenge with the virulent strain B goose parvovirus compared with 95% of gosling progeny of unvaccinated parents. Progeny of vaccinated and unvaccinated geese were placed on a farm on which Derzsy''s disease was present. During the 1st month of life mortality was 7.7% in the progeny of vaccinated geese compared with 59.8% in the progeny of the unvaccinated geese. At 8 wk of age the mean weight of the vaccinated goslings was 20% greater than for the unvaccinated goslings. The attenuated apathogenic Bav mutant is suitable for the immunization of layers to protect their progeny by passive immunization against Derzsy''s disease.

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