BASELINE AND INTERFERON‐ENHANCED NATURAL KILLER CELL ACTIVITY IN RHEUMATOID ARTHRITIS

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Abstract
Natural killer (NK) cell activity against the leukemia cell line K-562 was tested in 45 patients with rheumatoid arthritis (RA) who either had not received any remission-inducing drugs for > 6 months or had received penicillamine for at least 6 mo. Baseline NK cell activity and interferon (IF)-enhanced NK cell activity did not differ from that observed in 45 controls matched for age and sex, and neither NSAID (non steroidal anti-inflammatory drugs) nor penicillamine influenced NK cell activity. There was no correlation between NK cell activity and acute-phase reactants.