Mutagenicity of N-acylglycinohydroxamic acids and related compounds.

Publisher Website
Google Scholar
Abstract
The mutagenic activity of 29 new N-acylglycinohydroxamic acids and related compounds was tested on Bacillus subtilis (Rec+, Rec-) and Salmonella typhimurium (TA 98 and TA 100). All the N-(substituted-benzoyl)glycinohydroxamic acids, except the 3-acetylaminobenzoyl-derivative, were mutagenic to both test bacteria, whereas most of the N-aliphatic acylglycinohydroxamic acids were non-mutagenic. The structure-activity correlation between chemical structures and mutagenic activities were discussed. [The N-acylglycinohydroxamic acids are being tested as potential [human] urolithiasis treatments].