Congenital Hypoplastic Thrombocytopenia with Skeletal Deformities in Siblings

Abstract
The occurrence of congenital hypoplastic thrombocytopenia with absent radii is described in siblings. Both presented with hemorrhagic manifestations within a few weeks of birth and the first died at the age of six and a half months. Reference is made to two other examples in siblings. These abnormalities are considered as due to a genetic defect and the cases are probably variants of Fanconi’s syndrome.