Cu(I)-Catalyzed Reductive Aldol Cyclizations: Diastereo- and Enantioselective Synthesis of β-Hydroxylactones
- 16 August 2005
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (19) , 4225-4228
- https://doi.org/10.1021/ol051649h
Abstract
Copper bisphosphine complexes catalyze the intramolecular reductive aldol reaction of α,β-unsaturated esters with ketones, affording five- and six-membered β-hydroxylactones in high stereoselectivities. Utilization of chiral nonracemic bisphosphines render the cyclizations enantioselective.Keywords
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