Detection and Quantitation of Cannabinoids in Biological Fluids: Specificity and Kinetics after Smoking

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Abstract
A procedure for the quantitation and detection of cannabinoids in biological fluids (plasma and urine) was described. This method was based on isotopic derivatization and double labeling. .DELTA.9-Tetrahydrocannabinol [THC] and 2 metabolites (11-hydroxy-.DELTA.9-THC and 8-.beta.-hydroxy-.DELTA.9-THC) detected and measured in plasma or urine. Plasma was obtained from 2 morphine smoking addicts and urine was obtained from normal subjects, multiple drug addicts and hashish smokers. The use of TLC enabled specific separation of cannabinoids. The sensitivity of detection (4 ng/ml) was compatible with cannabinoid kinetics. This procedure can be applied to routine measurements and pharmacokinetic studies.

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