Effect of Decortication on Striatal Dopamine Turnover

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Abstract
In rat striatum, frontal decortication did not affect the basal and the haloperidol-induced increases in dopamine (DA) turnover and the elevation in DA and dihydroxyphenylacetic acid concentrations produced by systemic administration of L-Dopa. These findings fail to support a role for the corticostriatal afferents in modulation of dopamine synthesis and release by nigrostriatal neurons. They suggest that DA receptors presumably localized on presynaptic corticostriatal terminals do not mediate the acceleration of DA turnover induced by neuroleptics. Data also indicate that corticostriatal terminals do not represent a locus for decarboxylation of exogenous L-Dopa to DA in the striatum.

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