Activation of Human Basophils by Bacterial Products
- 1 January 1985
- journal article
- basophils
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 77 (1-2) , 213-215
- https://doi.org/10.1159/000233790
Abstract
Staphylococcus aureus Cowan I (Cowan Staph A+), which synthetizes protein A (Staph A), induced histamine release from human basophils. In contrast, S. aureus Wood 46 (Wood Staph A––), which does not synthetize Staph A, did not induce histamine secretion. Soluble Staph A and Cowan Staph A+ induced histamine release by interacting with the alternative F(ab′)2-binding site of IgE and/or IgG present on human basophils. Pepstatin A, a pentapeptide synthetized by various actinomycetes, induced histamine secretion by activating a specific membrane receptor, which is also activated by synthetic formylmethionine-containing peptides.Keywords
This publication has 0 references indexed in Scilit: