Inhibition by spermine of the inner membrane permeability transition of isolated rat heart mitochondria
- 30 November 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 313 (3) , 314-318
- https://doi.org/10.1016/0014-5793(92)81217-a
Abstract
The effect of spermine on the permeability transition of the inner mitochondrial membrane of isolated rat heart mitochondria was evaluated. The permeability transition was triggered using a series of agents (t-butyl hydroperoxide, phenylarsine oxide, carboxyatractylate, and elevated Ca2+ and inorganic phosphate concentrations), and was monitored via Ca2+-release, mitochondrial swelling and pyridine nucleotide oxidation. By all three criteria, spermine inhibited the transition. A C50 of 0.38 ± 0.06 (SD) mM was measured for inhibition.Keywords
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