Results of Microsurgery in Cushing’s Disease and Effect on Hypertension

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Abstract
In 100 consecutive transnasal sellar explorations in suspected Cushing’s disease, 88 pituitary adenomas were removed. The initial remission rate in adenoma cases was about 90%. Complications related to surgery had been rare. Regularly after complete selective adenomectomy a period of ACTH and cortisol deficiency was found (90%). In these patients only 1 recurrence was seen whereas from 5 patients without cortisol deficit a relapse occurred in 4. Hypertension was found in 80% of patients with verified Cushing’s disease. With normalization of cortisol excess, hypertension disappeared in 75% and was ameliorated in 15%.

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