Influence of the frequency parameter on extracellular glutamate and γ‐aminobutyric acid in substantia nigra and globus pallidus during electrical stimulation of subthalamic nucleus in rats
- 20 February 2003
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 72 (2) , 259-267
- https://doi.org/10.1002/jnr.10577
Abstract
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) proves to be an efficient treatment for alleviating motor symptoms in Parkinson's disease (PD). However, the mechanisms of HFS underlying these clinical effects remain unknown. Using intracerebral microdialysis, we previously reported that HFS induces, in normal rats, a significant increase of extracellular glutamate (Glu) in the globus pallidus (GP in rats or GPe in primates) and the substantia nigra pars reticulata (SNr), whereas γ-aminobutyric acid (GABA) was increased only in the SNr. Bradykinesia can be improved by STN stimulation in a frequency-dependent manner, a plateau being reached around 130 Hz. The aim of the present study was to determine whether neurochemical changes are also frequency dependent. Electrical STN stimulation was applied at various frequencies (10, 60, 130, and 350 Hz) in normal rats. The results show that, for Glu, the amplitude of increase detected in GP and SNr is maximal at 130 Hz and is maintained at 350 Hz. No modifications of GABA were observed in GP whatever the frequency applied, whereas, in SNr, GABA increased from 60 to 350 Hz. Our results provide new neurochemical data implicating STN target structures in deep-brain-stimulation mechanisms.Keywords
This publication has 54 references indexed in Scilit:
- Mechanisms of deep brain stimulationMovement Disorders, 2002
- Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: effects of variation in stimulation parametersJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Extracellular excitation of central neurons: implications for the mechanisms of deep brain stimulationThalamus & Related Systems, 2001
- Axial parkinsonian symptoms can be improved: the role of levodopa and bilateral subthalamic stimulationJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Bilateral subthalamic nucleus stimulation improves frontal cortex function in Parkinson's diseaseBrain, 1999
- Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulationMovement Disorders, 1998
- Reversal of Rigidity and Improvement in Motor Performance by Subthalamic High‐frequency Stimulation in MPTP‐treated MonkeysEuropean Journal of Neuroscience, 1993
- Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleusThe Lancet, 1991
- Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological dataBrain Research, 1990
- An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusatesLife Sciences, 1988