Clostridium botulinum toxins: nature and preparation for clinical use
- 1 January 1988
- journal article
- Published by Springer Nature in Eye
- Vol. 2 (1) , 16-23
- https://doi.org/10.1038/eye.1988.5
Abstract
C. botulinum neurotoxins are acutely toxic materials and act by inhibiting release of the neurotransmitter acetylcholine. The specific nature of this inhibition is discussed and the preparation and purification of Type A toxin specifically for clinical use is described.Keywords
This publication has 32 references indexed in Scilit:
- DOUBLE-BLIND STUDY OF BOTULINUM TOXIN IN SPASMODIC TORTICOLLISThe Lancet, 1986
- IMPROVEMENT IN TREATMENT FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKAEMIA: The Medical Research Council UKALL Trials, 1972-84The Lancet, 1986
- Inactivation of Clostridium botulinum type A neurotoxin by trypsin and purification of two tryptic fragmentsEuropean Journal of Biochemistry, 1985
- Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalizationNature, 1984
- Radioiodination of Botulinum Neurotoxin Type A with Retention of Biological Activity and Its Binding to Brain SynaptosomesEuropean Journal of Biochemistry, 1983
- Preparation and Characterisation of Homogeneous Neurotoxin Type A from Clostridium botulinumEuropean Journal of Biochemistry, 1982
- Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system.The Journal of cell biology, 1979
- Restoration of transmitter release in botulinum-poisoned skeletal muscleBrain Research, 1976
- The interaction between divalent cations and botulinum toxin type a in the paralysis of the rat phrenic nerve-hemidiaphragm preparationNeuropharmacology, 1973
- Ionic requirements for the neuromuscular blocking action of botulinum toxin: Implications with regard to synaptic transmissionNeuropharmacology, 1971