Sickle-Cell Anemia
- 1 July 1961
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 108 (1) , 109-113
- https://doi.org/10.1001/archinte.1961.03620070111014
Abstract
Sickle-cell anemia is a chronic hemolytic anemia affecting persons of Negro descent who have inherited a gene from both parents1 that controls the formation of an abnormal hemoglobin (hemoglobin S). This differs from normal hemoglobin (hemoglobin A) in amino-acid composition,2 electrophoretic mobility,3 solubility,4 and affinity for oxygen.5 When deprived of oxygen, hemoglobin S undergoes molecular rearrangement,3 and the erythrocytes become altered in shape. The diagnosis of sickle-cell anemia is established by: In sickle-cell anemiaThis publication has 0 references indexed in Scilit: