Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillin
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 13,p. 495-496
- https://doi.org/10.1039/c39760000495
Abstract
The rate law for the aminolysis of benzylpenicillin is obtained and Brønsted β-values indicate that the general-base-catalysed reaction occurs with a stepwise proton-transfer step; intramolecular general base catalysis occurs in the reaction of ethylenediamine with penicillin.This publication has 2 references indexed in Scilit:
- A New Chemical Aspect of Penicillin Allergy: The Direct Reaction of Penicillin with ɛ-Amino-GroupsNature, 1965
- Studies on the formation of the penicillin antigen. II. Some reactions of d-benzylpenicillenic acid in aqueous solution at pH 7.5Archives of Biochemistry and Biophysics, 1961