THE EFFECT OF CERTAIN ETHYLENEIMINES ON RENAL FUNCTION
Open Access
- 30 November 1963
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 21 (3) , 581-589
- https://doi.org/10.1111/j.1476-5381.1963.tb02025.x
Abstract
Certain simple derivatives of ethyleneimine cause an intense and prolonged diuresis in nonhydrated rats. Sodium, potassium and chloride excretion is unaffected by these compounds. Ethyleneimine also causes a diuresis in the rat, but the poly-functional compound thiotepa is ineffective. The relationship between structure and activity of a number of compounds is discussed with particular reference to the possibility that the diuresis is due to the in vivo liberation of ethyleneimine.Keywords
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