Role of Peroxisome Proliferator-Activated Receptor-γ in the Glucose-Sensing Apparatus of Liver and β-Cells
Open Access
- 1 February 2004
- journal article
- review article
- Published by American Diabetes Association in Diabetes
- Vol. 53 (suppl_1) , S60-S65
- https://doi.org/10.2337/diabetes.53.2007.s60
Abstract
Type 2 diabetes develops in the context of both insulin resistance and β-cell failure. Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin sensitivity in various animal models of diabetes. The improved insulin sensitivity may be achieved either by systemic insulin sensitization or by direct action of peroxisome proliferator-activated receptor (PPAR)-γ on the transcription of genes involved in glucose disposal. Evidence supporting the direct action of PPAR-γ on glucose metabolism is observed in the genes involved in insulin-stimulated glucose disposal. We already showed that GLUT2 and β-glucokinase were directly activated by PPAR-γ. Recently, we have identified and characterized the functional PPAR response element in the GLUT2 and liver type glucokinase (LGK) promoter of the liver. It is well known that adipose tissue plays a crucial role in antidiabetic action of PPAR-γ. In addition, PPAR-γ can directly affect liver and pancreatic β-cells to improve glucose homeostasis.Keywords
This publication has 53 references indexed in Scilit:
- Lipotoxic DiseasesAnnual Review of Medicine, 2002
- Glucose-induced Toxicity in Insulin-producing Pituitary Cells That Coexpress GLUT2 and GlucokinaseJournal of Biological Chemistry, 2001
- Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive TissuesEndocrinology, 2001
- Effects of Troglitazone on Cellular Differentiation, Insulin Signaling, and Glucose Metabolism in Cultured Human Skeletal Muscle CellsBiochemical and Biophysical Research Communications, 2001
- Thiazolidinediones (PPARγ agonists) but not PPAR α agonists increase IRS‐2 gene expression in 3T3‐L1 and human adipocytes1The FASEB Journal, 2000
- Cloning and Characterization of a Functional Peroxisome Proliferator Activator Receptor-γ-responsive Element in the Promoter of the CAP GeneJournal of Biological Chemistry, 2000
- Regulation of Gene Expression by Activation of the Peroxisome Proliferator-Activated Receptor γ with Rosiglitazone (BRL 49653) in Human AdipocytesBiochemical and Biophysical Research Communications, 1999
- Glucose-6-phosphatase Overexpression Lowers Glucose 6-Phosphate and Inhibits Glycogen Synthesis and Glycolysis in Hepatocytes without Affecting Glucokinase TranslocationJournal of Biological Chemistry, 1999
- Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre RecombinaseJournal of Biological Chemistry, 1999
- Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.Journal of Clinical Investigation, 1997