Development of Resistance to the Juvenoid Methoprene in the House Fly1

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Abstract
High levels of resistance (>1000-fold) to the juvenoid methoprene have been induced in a dimethoate-resistant laboratory strain as well as in a field multiresistant strain of Musca domestica L. by exposure of mature larvae to methoprene-treated pupation medium. Resistance extended also to 3 other juvenoids tested. However, cross resistance to dimethoate, fenthion, parathion, and Isolan (1-isopropyl-3-methyl-5-pyrazolyl dimethylcarbamate), originally present in the dimethoate-R strain, has declined during the course of selection by methoprene.

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