Studies On the Inhibition of Xanthine Oxidase.
- 1 June 1945
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 59 (2) , 287-289
- https://doi.org/10.3181/00379727-59-15059
Abstract
Summary The repeated intravenous administration of increasing doses 0.5 to 4.0 g of p-aminophenol to a patient with gout did not affect the uric acid output in the urine or the blood uric acid level; occasionally there was transient elevation of temperature and nausea. Free iodine, in .008 M solution, caused an 88% inhibition of milk xanthine oxidase but was not specific for this enzyme. 0.001 M pyrogallol inhibited xanthine oxidase approximately 44% and had no effect upon other enzymes like uricase. Many other substances were tested and found to cause no appreciable inhibition of xanthine oxidase.Keywords
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