Effect of histidine on morphine-induced changes in brain histamine
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 7 (5-6) , 495-500
- https://doi.org/10.1007/bf02111120
Abstract
Chronic morphine administration to rats resulted in a significant decrease in the hypothalamic and cerebro-cortical histamine concentrations. These low histamine values were restored to control levels whenl-histidine was administered daily along with morphine treatment. Chronic treatment withl-histidine prevented the midbrain and cerebro-cortical histamine depletion in morphine-withdrawn rats, whereas in the hypothalamus the histamine level remained significantly decreased. The present data suggests that histamine may play a role in morphine dependence and withdrawal.This publication has 26 references indexed in Scilit:
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