The effect of cisplatin and platinum(IV)chloride on cell growth, RNA, protein, ribosome and DNA synthesis in yeast

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Abstract
The effect of cisplatin and platinum(IV)chloride on growth, RNA, ribosome, and DNA synthesis were tested in growing yeast cells. Treatment with both compounds causes comparable reduction but not a significant delay in the course of growth and RNA synthesis as well as DNA, and ribosome synthesis rates. The results were evaluated on the basis of a test system for rapid differentiation of nuclear and cytoplasmatic damage, which is founded on qualitative changes in growth curves and in synthesis rates. These observations indicate that PtCl4 as well as cisplatin cause defects in the nuclear DNA. A quantitative comparison suggests that there exist differences in the nature of the DNA damage.