Plasma Heparin Levels in Man Following Intravenous Fat Emulsions

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Abstract
Plasma heparin levels were determined in duplicate in 18 individuals before, during and after intravenous infusion of cottonseed oil emulsion, and in 14 of the group after control injection without fat. There was an average increase of 22% in circulating heparin in 12 of the 18 subjects after the fat emulsion; an average increase of 18% in 4 of the 14 patients after non-fat emulsion. The results indicate that fat intake is a stimulus for the release of heparin into the bloodstream. Heparin may be normally involved in the removal of fat from the bloodstream.