Antispasmodic Activity of Thymus vulgaris Extract on the Isolated Guinea-Pig Trachea: Discrimination Between Drug and Ethanol Effects
- 1 August 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 65 (6) , 512-516
- https://doi.org/10.1055/s-1999-14006
Abstract
The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F2α). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F 2α being most efficiently antagonized.Keywords
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