Oral Terbutaline Sulfate—Amelioration of Exercise‐Induced Bronchospasm

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Abstract
Bronchospasm can be induced in asthmatics when exercised according to a multistage branching treadmill protocol that allows them to achieve 80% of their age-predicted maximal heart rate. The effect of oral terbutaline sulfate was studied in ameliorating exercise-induced bronchospasm. Ten asthmatics were exercised, and FEV1.0 [forced expiratory vol in 1 s] and MMEFR [maximum midexpiratory flow rate] were assessed while standing, using a Jones Pulmonar II waterless spirometer at 5, 15 and 30 min after exercise. Three hours before exercise, the subjects received either no medication, oral placebo or 5 mg terbutaline sulfate orally. At all time intervals after exercise, the pulmonary function of the group pretreated with oral terbutaline was superior when compared to the no-medication group (P < 0.01) and to the placebo-treated group (P < 0.05). Oral terbutaline normalized the exercise tolerance of the asthmatics and restored physiologic pulmonary airway conductance by the parameters of FEV1.0 and MMEFR.

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