Role of the Autonomic Nervous System in the Genesis of Early Ischemic Arrhythmias

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Abstract
The first minutes of myocardial ischemia are accompanied by a transient phase of cardiac electrical instability with special features, known as “phase 1a.” The activation of the autonomic nervous system, associated with the onset of ischemia, seems to play a major role in the genesis of phase 1a arrhythmias and is potentially responsible for their unique characteristics. In this article, the relative influence of the sympathetic and parasympathetic components of cardiac neural activity on the ventricular electrical properties during early ischemia will be discussed. To study the influence of neural activity on acutely ischemic myocardium, and to evaluate the efficacy of antiarrhythmic interventions in conditions of sympathetic hyperactivity, we developed two different experimental models.

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