Inhibition of Diffusion Chamber (DC) Granulopoiesis by Anti-CSF Serum

Abstract
Diffusion chamber granulopoiesis was studied in irradiated mice injected with anti-CSF [colony stimulating factor] serum. Total cellularity, proliferative and nonproliferative granulocytes were markedly suppressed by 4 days injection of antiserum. Granulocytic stem cells were markedly decreased. CSF apparently is necessary for maintaining the integrity of the granulocytic stem cell and for inducing differentiating granulopoiesis.

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