EFFECT OF SELENIUM IN COMBINATION WITH CIS-DIAMMINEDICHLOROPLATINUM(II) IN THE TREATMENT OF MURINE FIBRO-SARCOMA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (7) , 2864-2868
Abstract
The use of cis-diamminedichloroplatinum(II) (cis-DDP), an anticancer agent, is limited by its toxicity. Since it has been demonstrated that SE is able to combine with metals like Cd and Hg and to reduce their toxicity, its effect on the toxicity of Pt was studied. Fibrosarcoma-bearing mice were treated with a combination of cis-DDP and Se. The dose of 2 or 4 .mu.g Se/g animal weight had no effect on tumor growth. The i.p. injection of 16 .mu.g cis-DDP/g led to early death of animals. The i.p. treatment of tumor-bearing animals with 2 or 4 .mu.g of Se reduced the early mortality induced by cis-DDP at a dose of 16 .mu.g/g. The addition of Se allowed the administration of high doses of cis-DDP, which resulted in an improved antitumor effect. Clonogenic assays following drug exposure showed that Se had no direct effect on tumor cells and did not modify the antitumor activity of cis-DDP. EM showed reduced changes in renal cells when Se was added to the cis-DDP treatment. Microanalysis showed no accumulation of either Se or Pt within renal cells. The addition of Se decreases the nephrotoxicity of cis-DDP.