Immunohistochemical Demonstration of Peptide Hormones in Cervical; Adenocarcinomas with Argyrophil Cells

Abstract
Thirty patients with cervical adenocarcinoma were analyzed clinicopathologically with special reference to argyrophil cells. In contrast to argyrophil small cell carcinoma of the cervix, 4 adenocarcinomas with argyrophil cells were not more aggressive than the remaining 26 usual ones. One or 2 peptide hormones were demonstrated in 3 of 4 tumors with argyrophil cells which were examined by immunohistochemistry. Somatostatin- and gastrin-containing cells were found in 1 tumor, but were located differently from each other. Either gastrin- or ACTH-containing cells were detected in 2 other tumors. They all corresponded to argyrophil cells, but were less numerous.

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