Full-Length Characterization of Proteins in Human Populations
Open Access
- 1 February 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 56 (2) , 202-211
- https://doi.org/10.1373/clinchem.2009.134858
Abstract
Background: Diversity in human proteins often gives rise to pluralities of structurally similar but functionally distinct proteins. Such microheterogeneity generally escapes proteomics discovery technologies, as well as conventional immunometric assays. As an intermediate between these 2 technological approaches, targeted, full-length characterization of proteins using mass spectrometry is a suitable means of defining microheterogeneity evident in human populations.Keywords
This publication has 34 references indexed in Scilit:
- Mass spectrometry-based immunoassays for the next phase of clinical applicationsExpert Review of Proteomics, 2006
- Multiplexed Mass Spectrometric Immunoassay in Biomarker Research: A Novel Approach to the Determination of a Myocardial InfarctJournal of Proteome Research, 2006
- Quantitative Multiplexed C-Reactive Protein Mass Spectrometric ImmunoassayJournal of Proteome Research, 2006
- Quantitative Mass Spectrometric Immunoassay of Insulin Like Growth Factor 1Journal of Proteome Research, 2004
- High-Throughput Comprehensive Analysis of Human Plasma Proteins: A Step toward Population ProteomicsAnalytical Chemistry, 2004
- Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteinsJournal of Lipid Research, 2003
- High-Throughput Protein Characterization Using Mass Spectrometric ImmunoassayAnalytical Biochemistry, 2002
- Determination of β-2 Microglobulin Levels in Plasma Using a High-Throughput Mass Spectrometric Immunoassay SystemAnalytical Chemistry, 2001
- Detection and Quantification of β-2-Microglobulin Using Mass Spectrometric ImmunoassayAnalytical Biochemistry, 2001
- Mass Spectrometric ImmunoassayAnalytical Chemistry, 1995