Adenosine Cyclic 3′, 5′-Phosphoramidate and N,N-Dimethylphosphoramidate: Synthesis Via Symmetrical and Mixed Anhydrides and Hydrolysis
- 1 April 1987
- journal article
- research article
- Published by Taylor & Francis in Phosphorus and Sulfur and the Related Elements
- Vol. 30 (3-4) , 597-600
- https://doi.org/10.1080/03086648708079136
Abstract
The title compounds were synthesized by converting cyclic AMP with a sulfonyl chloride to the symmetrical anhydride or with diphenyl phosphorochloridate to the mixed anhydride, then aminolyzing the anhydrides without isolation. The synthesis preferentially gave Sp-amides. Characteristic differences were observed in the behavior of the unsubstituted amide and the dimethylamide under hydrolysis conditions.Keywords
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