Histopathology Induced by Larval Terranova (Type HA) (Nematoda: Anisakinae) in Experimentally Infected Rats

Abstract
Terranova Type Hawaii A larvae, gavaged into the stomach of Wistar rats, demonstrated the ability to invade the stomach and intestinal tissues of the rat without penetrating the serosa. Lesions induced by these 3rd-stage larvae were present in 25 of 37 (68%) inoculated rats. Larvae adhered to the mucosa of the stomach within 1 h PI [postinfection]. Mucosal ulceration and acute, focal, hemorrhagic areas in the mucosa and submucosa were associated with most worm-penetrations. Reactions of inflammatory tissue occurred from 4 h to 5 days PI and granulomas occurred by day 7 PI. Indurated craterlike lesions were noted 10-15 days PI. Resolving granulomas were presented by day 30 PI. Chronic gastric ulcers were observed at day 30 PI.

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