Decomposition of thiamine in alcohol solution. I.

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Abstract
Thiamine monochloride (Ia) was found to easily decompose in methanol solution to produce a crystalline compound X (II), which is believed to be derived from the pyrimidine part of thiamine, and 5-(2-hydroxyethyl)-3-methylthiazole (III). The ratio and rate of this decomposition are affected by the kind of alcohol, its dilution rate, reaction temperature, the acidity and basicity of the solution and concentration of Ia. Decomposition of Ia in methanol in the presence of pyridine gave N-[2-methyl-4-aminopyrimidyl-(5)]-methylpyridinium chloride (V) and III.

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