The curious case of protein splicing: Mechanistic insights suggested by protein semisynthesis
- 1 May 1993
- journal article
- review article
- Published by Wiley in Protein Science
- Vol. 2 (5) , 697-705
- https://doi.org/10.1002/pro.5560020501
Abstract
The gradual accumulation of examples of protein splicing, in which a nested intervening sequence is spliced out of the interior of a polyprotein precursor, suggests that this curious phenomenon might prove to have universal phylogenetic distribution and biological significance. The known examples are reviewed, with the aim of establishing underlying patterns, and a generalized mechanism of autocatalytic protein splicing is proposed. The testable consequences of such a proposal and the possible evolutionary origins of the phenomenon are discussed.Keywords
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