Measurement of Myocardial Blood Flow in Animals and Man by Selective Injection of Radioactive Inert Gas into the Coronary Arteries

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Abstract
1. Human myocardial blood flow has been measured by the determination of precordial radioactivity after the injection of solutions of radioactive gas directly into the coronary arteries following coronary arteriography. 2. The accuracy of radioactive gas measurements has been established in dog experiments by comparison with coronary blood flow simultaneously measured by rotameter. 3. This method has two major advantages over the existing methods of measuring human myocardial blood flow. Firstly, the right and left coronary circulations can be studied separately, this being the only method whereby the right circulation can be studied in man. Secondly, anatomical and physiological correlations are readily available as arteriography is an essential feature of the method.