Detoxification of an immunogenic fraction from a culture filtrate of Pseudomonas aeruginosa

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Abstract
Mice immunized with a fraction from a culture filtrate of Ps. aeruginosa, then burned and infected with virulent serotypes of Ps. aeroginosa, were protected from septicaemia and death.The immunogenic fraction killed mice at dosages 400 times those of the minimum protective dosages.Treatment of the immunogenic fraction with 0·5% formalin reduced its lethal effect for mice and slightly improved its immunizing potency so that the difference between the smallest immunizing dose used and the smallest amount that killed mice was more than 80,000 doses.